Understanding the genetic causes of FSGS and steroid-resistant nephrotic syndrome
Integrating large scale genomics and functional studies to accelerate FSGS/NS discovery
This study is looking at the genes of about 10,000 people with focal and segmental glomerulosclerosis (FSGS) and steroid-resistant nephrotic syndrome (SRNS) to find out how these genes affect their treatment and health, with the hope of improving diagnosis and creating better treatment options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10891546 on NIH RePORTER |
What this research studies
This research focuses on a large cohort of approximately 10,000 patients with focal and segmental glomerulosclerosis (FSGS) and steroid-resistant nephrotic syndrome (SRNS) to explore the genetic underpinnings of these conditions. By utilizing genome-wide sequencing data, the researchers aim to identify specific genetic mutations that contribute to these diseases. The study will also investigate how these genetic factors influence treatment responses and outcomes, particularly in relation to steroid therapies and renal transplant planning. The goal is to enhance diagnostic accuracy and develop targeted therapeutic strategies based on genetic findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with focal and segmental glomerulosclerosis or steroid-resistant nephrotic syndrome.
Not a fit: Patients with other types of kidney diseases unrelated to FSGS or SRNS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment options for patients with FSGS and SRNS.
How similar studies have performed: Previous research has shown success in identifying genetic factors in similar kidney diseases, indicating a promising approach for this study.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Pollak, Martin R. — Beth Israel Deaconess Medical Center
- Study coordinator: Pollak, Martin R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.