Understanding the genetic causes of early-onset Alzheimer's disease
Dissecting the Genomic Etiology of non-Mendelian Early-Onset Alzheimer Disease and Related Phenotypes
This study is looking at the genetic causes of early-onset Alzheimer's disease in people who don’t have known gene mutations, and it’s inviting individuals from different backgrounds to help find new genetic clues that could lead to better treatments and a deeper understanding of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10667461 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to early-onset Alzheimer's disease (EOAD), particularly in cases that do not involve known mutations in specific genes. By conducting large-scale whole-genome sequencing, the study aims to identify new genetic variants associated with EOAD. Participants will include individuals from diverse backgrounds, allowing for a comprehensive understanding of the disease's genetic architecture. The findings could lead to the discovery of novel therapeutic targets and improve our understanding of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with early-onset Alzheimer's disease who do not have known mutations in the APP, PSEN1, or PSEN2 genes.
Not a fit: Patients with late-onset Alzheimer's disease or those with known genetic mutations related to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and interventions for early-onset Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic factors in Alzheimer's disease, but this approach focusing on unexplained EOAD cases is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Beecham, Gary Wayne — University of Miami School of Medicine
- Study coordinator: Beecham, Gary Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.