Understanding the genetic causes of Chiari type I malformation and its effects on brain development
Official title: Genetic Underpinnings of CM and SM and Effect on Brain Development
Funded at Washington University · NIH-10876268 · Data updated 2026-11-12
This study is looking at the genes that might cause Chiari type I malformation in kids, using zebrafish to see how these genes affect brain and spine development, with the goal of helping doctors make better decisions about diagnosis and treatment for kids with this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $85,299 |
| NIH project number | 5P01NS131131-02 |
| Project ID | NIH-10876268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with Chiari type I malformation or related conditions.
✕Less likely to help
Patients without Chiari type I malformation or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to Chiari type I malformation (CM1), a common pediatric neurological condition. By identifying genetic variations and their impact on brain and spinal development, the study aims to improve diagnostic accuracy and treatment options for affected patients. The researchers will use zebrafish models to explore how specific genetic changes influence brain structure and function. Ultimately, this work seeks to enhance clinical decision-making regarding surgical interventions for CM1.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses for patients with Chiari type I malformation, improving treatment outcomes.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to neurological conditions, suggesting potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Haller, Gabriel E — Washington University
- Study coordinator: Haller, Gabriel E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.