Understanding the genetic causes of cerebral palsy in families with multiple affected children
Genomic analysis of the Multiplex, Autozygous Populations in Cerebral Palsy (MAP CP) cohort: a focused approach to a complex disease
This study is looking at the genes of families with more than one child who has cerebral palsy to find out what specific genetic changes might cause the condition, which could help improve how we understand and treat CP in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11090328 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to cerebral palsy (CP) by focusing on families with multiple children affected by the condition. By analyzing the genomes of these families, the study aims to identify specific genetic mutations that may lead to CP symptoms. This approach differs from traditional studies that typically examine parent-child genetic relationships, allowing for a deeper understanding of hereditary patterns in CP. The findings could significantly impact how CP is managed and treated in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are families with multiple children diagnosed with cerebral palsy, particularly those with a suspected genetic component.
Not a fit: Patients with cerebral palsy who do not have a familial history or genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management strategies for children with cerebral palsy based on their genetic profiles.
How similar studies have performed: Previous research has shown promise in identifying genetic causes of cerebral palsy, but this specific approach focusing on multiplex families is relatively novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Kruer, Michael C — University of Arizona
- Study coordinator: Kruer, Michael C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.