Understanding the genetic causes of Alzheimer's disease in African Americans
The Origins of Alzheimer Disease in African Americans
This study is looking at how genes might affect the risk of Alzheimer's disease in African Americans, a group that hasn't been studied as much in the past, to help find better ways to prevent the disease for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10872233 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to Alzheimer's disease (AD) risk specifically in African Americans, a group that has been historically underrepresented in genetic studies. By analyzing genetic data and family histories, the research aims to identify unique risk patterns and potential environmental influences that may affect AD prevalence in this population. The study will utilize advanced genetic tools and larger sample sizes to uncover rare genetic variants and improve risk prediction for Alzheimer's disease. Ultimately, the goal is to enhance understanding of AD and inform prevention strategies tailored to African American individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals who may be at risk for Alzheimer's disease due to genetic or environmental factors.
Not a fit: Patients who do not identify as African American or those who do not have a family history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and targeted treatments for Alzheimer's disease in African Americans.
How similar studies have performed: Previous research has shown that genetic studies focusing on diverse populations can reveal significant differences in disease risk, indicating that this approach has potential for success.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.