Understanding the genetic causes of Alzheimer's disease and related dementias
Identifying the Genetic Etiology of Neuropathology for Alzheimer Disease and Related Dementias
This study is looking at how our genes might affect the brain changes that happen in Alzheimer's disease and similar conditions, so we can better understand why some people have different brain injuries and help improve diagnosis and treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10612832 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the brain changes seen in Alzheimer's disease and related dementias. By examining the complex mix of brain lesions, including neuritic plaques and neurofibrillary tangles, the study aims to identify how different genetic variants influence these conditions. Patients with Alzheimer's often have additional brain injuries that complicate their diagnosis, and this research seeks to clarify the genetic underpinnings of these variations. Through a combination of genetic analysis and neuropathological assessment, the study hopes to provide insights into the mechanisms of cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults diagnosed with Alzheimer's disease or related dementias, particularly those with complex neuropathological profiles.
Not a fit: Patients without a diagnosis of Alzheimer's disease or related dementias, or those with other unrelated neurological conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors associated with Alzheimer's disease, but this study aims to explore a more complex and nuanced approach.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Beecham, Gary Wayne — University of Miami School of Medicine
- Study coordinator: Beecham, Gary Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.