Understanding the Genetic Causes of Adolescent Scoliosis
Human Genetics and Clinical Translation
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11121815
This project aims to discover the biological reasons why some children develop adolescent idiopathic scoliosis, a twisting of the spine.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11121815 on ClinicalTrials.gov |
What this research studies
Adolescent idiopathic scoliosis (AIS) is a common spine condition in children, particularly girls, leading to disfigurement and pain. Currently, treatments only address symptoms because we don't know what causes it. This research looks into the genetic and biological factors that contribute to AIS, building on past findings that identified specific genes and tissue components involved. By studying these factors, including using models like zebrafish, we hope to uncover the exact mechanisms behind the condition.
Who could benefit from this research
Good fit: This research is most relevant to children and adolescents, especially girls, who are affected by or at risk for adolescent idiopathic scoliosis.
Not a fit: Patients with other types of scoliosis or spinal conditions not related to adolescent idiopathic scoliosis may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis, new ways to prevent scoliosis from worsening, and non-surgical treatments for children with AIS.
How similar studies have performed: Previous work supported by this grant has already identified several genetic factors and tissue components linked to AIS, suggesting a promising path forward.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WISE, CAROL A — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: WISE, CAROL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.