Understanding the genetic basis of brain connections
Official title: Transcriptional basis of stereotyped neural architectures
Funded at New York University · NIH-11079630 · Data updated 2026-11-12
This study is looking at how our genes affect the way brain connections are formed and kept, which could help us understand more about mental health issues like autism, so patients can learn how their brain's structure is shaped by genetics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $207,857 |
| NIH project number | 5R00MH128772-04 |
| Project ID | NIH-11079630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related conditions.
✕Less likely to help
Patients with no neurological or psychiatric conditions may not receive direct benefits from this research.
What this research studies
This research investigates how specific genetic programs influence the formation and maintenance of neural connections in the brain. By utilizing advanced imaging techniques and single-cell RNA sequencing, the study aims to decode the genetic factors that determine synaptic connectivity. The findings could provide insights into the biological mechanisms underlying mental health disorders, particularly those related to autism spectrum disorder. Patients may benefit from a better understanding of how their brain architecture is influenced by genetics.
Why it matters
Potential benefit: If successful, this research could lead to new genetic targets for treating mental health disorders associated with brain connectivity.
How similar studies have gone: Other research has shown promise in understanding genetic influences on brain architecture, making this approach both relevant and potentially impactful.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Varol, Erdem — New York University
- Study coordinator: Varol, Erdem
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.