Understanding the genetic and social factors affecting heart failure in people with congenital heart disease
Official title: Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart disease
Funded at Duke University · NIH-10850808 · Data updated 2026-11-12
This study is looking at how genes and social factors affect heart failure and survival in people with congenital heart disease, and it's designed to help improve care for those at higher risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $667,938 |
| NIH project number | 5R01HL166217-02 |
| Project ID | NIH-10850808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital heart disease, particularly those who are adults or transitioning into adulthood.
✕Less likely to help
Patients without congenital heart disease or those who are not within the age range of 21 years and older may not benefit from this research.
What this research studies
This research investigates the genetic and social determinants that contribute to heart failure and mortality in individuals with congenital heart disease (CHD). By leveraging a multi-disciplinary team and a comprehensive surveillance network, the study aims to identify risk factors across the lifespan of CHD patients. Participants will be enrolled in a cohort that links clinical records with extensive databases, allowing for in-depth analysis of health outcomes and genetic information. The ultimate goal is to improve management strategies for those at high risk of heart failure.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of heart failure risk in patients with congenital heart disease, potentially improving their quality of life and longevity.
How similar studies have gone: Previous research has shown success in identifying risk factors for heart failure in congenital heart disease populations, making this approach both relevant and promising.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Landstrom, Andrew P. — Duke University
- Study coordinator: Landstrom, Andrew P.
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.