Understanding the genetic and molecular causes of lupus using advanced cell analysis techniques
Official title: Mapping the cell-type-specific molecular and genetic basis of lupus using single cell multiomics
Funded at University of California, San Francisco · NIH-11021015 · Data updated 2026-11-12
This study is looking at how certain genes and immune cells affect systemic lupus erythematosus (SLE) to help us understand the disease better and improve treatments, especially for people from different ethnic backgrounds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $783,273 |
| NIH project number | 5R01AI171184-02 |
| Project ID | NIH-11021015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those of Asian, African, or Hispanic descent.
✕Less likely to help
Patients without a diagnosis of systemic lupus erythematosus or those not of the targeted ancestries may not benefit from this research.
What this research studies
This research investigates systemic lupus erythematosus (SLE), an autoimmune disease that affects various organ systems and is more common in certain ethnic groups. By employing cutting-edge single-cell multiomics technology, the study aims to identify specific genetic and molecular factors that contribute to the disease's onset and progression. Patients will be analyzed at the cellular level to understand how their immune cells respond to treatments and environmental triggers. The research will also explore how genetic variations influence disease characteristics and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for lupus patients.
How similar studies have gone: Previous research using single-cell sequencing techniques has shown promise in understanding complex autoimmune diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ye, Chun Jimmie — University of California, San Francisco
- Study coordinator: Ye, Chun Jimmie
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.