Understanding the genetic and evolutionary factors of gut fungi in humans
The genetic, symbiotic, and evolutionary bases of the human gut mycobiome
This study is looking at how our genes and evolution affect the different types of fungi in our guts, especially by comparing twins, to help us understand how these tiny organisms work together and impact our overall gut health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11068587 on NIH RePORTER |
What this research studies
This research investigates the role of genetic and evolutionary factors in shaping the diversity and composition of gut fungi in humans. By studying the gut mycobiome of monozygotic and dizygotic twins, the research aims to uncover how genetic variants and gut bacteria interact to influence gut health. The approach includes sequencing the gut mycobiome and analyzing the relationships between heritable gut fungi and bacteria. This could provide insights into the complex interactions within the gut ecosystem and their implications for human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are part of the TwinsUK cohort, particularly monozygotic and dizygotic twins.
Not a fit: Patients who are not part of the TwinsUK cohort or those with conditions that significantly alter their gut microbiome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gut health and its relationship with genetic factors, potentially informing personalized dietary and therapeutic strategies.
How similar studies have performed: While studies have focused on gut bacteria, this research is novel as it specifically addresses the genetic and evolutionary aspects of the gut mycobiome, which have been less explored.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Van Syoc, Emily P — Pennsylvania State University, the
- Study coordinator: Van Syoc, Emily P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.