Understanding the genetic and epigenetic factors of otosclerosis
Official title: The genomic and epigenomic landscape of otosclerosis
Funded at University of Arizona · NIH-11046083 · Data updated 2026-11-12
This study is looking into otosclerosis, a hearing problem that often affects middle-aged people, to find out more about its causes by examining genetic information from patients, and we’d love for you to join us by sharing samples and helping us learn more about this condition!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | March 12, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $533,978 |
| NIH project number | 1R01DC021686-01A1 |
| Project ID | NIH-11046083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with otosclerosis, particularly those experiencing hearing loss in their 30s or 40s.
✕Less likely to help
Patients with otosclerosis who are not willing to participate in genetic testing or those with other unrelated hearing disorders may not benefit from this research.
What this research studies
This research investigates otosclerosis, a bone disorder that affects hearing, particularly in middle-aged individuals. By analyzing genetic and epigenetic data from a large group of patients, the study aims to uncover the underlying molecular mechanisms of the disease. The research will utilize advanced genomic techniques to identify potential genetic factors and their roles in the progression of otosclerosis. Patients may be asked to provide samples and participate in assessments to help advance our understanding of this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for otosclerosis, enhancing patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in similar bone disorders, suggesting potential for success in this area as well.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Schrauwen, Isabelle Veerle Suzanne — University of Arizona
- Study coordinator: Schrauwen, Isabelle Veerle Suzanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.