Understanding the genetic and epigenetic factors of otosclerosis
The genomic and epigenomic landscape of otosclerosis
This study is looking into otosclerosis, a hearing problem that often affects middle-aged people, to find out more about its causes by examining genetic information from patients, and we’d love for you to join us by sharing samples and helping us learn more about this condition!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11046083 on NIH RePORTER |
What this research studies
This research investigates otosclerosis, a bone disorder that affects hearing, particularly in middle-aged individuals. By analyzing genetic and epigenetic data from a large group of patients, the study aims to uncover the underlying molecular mechanisms of the disease. The research will utilize advanced genomic techniques to identify potential genetic factors and their roles in the progression of otosclerosis. Patients may be asked to provide samples and participate in assessments to help advance our understanding of this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with otosclerosis, particularly those experiencing hearing loss in their 30s or 40s.
Not a fit: Patients with otosclerosis who are not willing to participate in genetic testing or those with other unrelated hearing disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for otosclerosis, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in similar bone disorders, suggesting potential for success in this area as well.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Schrauwen, Isabelle Veerle Suzanne — University of Arizona
- Study coordinator: Schrauwen, Isabelle Veerle Suzanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.