Understanding the genetic and epigenetic factors of human pain
Data Core
This study is looking at human tissue samples to better understand how our bodies feel and process pain, using advanced techniques to uncover the biological factors involved, and it aims to help researchers learn more about pain by combining this information with patients' experiences and backgrounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928101 on NIH RePORTER |
What this research studies
This research focuses on analyzing human tissue samples to create extensive datasets that reveal the genetic and epigenetic mechanisms involved in pain perception and processing. By utilizing advanced techniques like single-cell RNA sequencing and ATAC sequencing, the project aims to uncover the biological pathways that contribute to pain. The Data Core will manage and harmonize these datasets, making them accessible for further analysis and collaboration among researchers. Patients' clinical data, including pain scores and demographics, will also be integrated to enhance the understanding of pain mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic pain conditions who are willing to provide tissue samples for analysis.
Not a fit: Patients with acute pain or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for managing chronic pain conditions.
How similar studies have performed: Previous research using multi-omics approaches has shown promise in understanding complex biological processes, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dong, Xianjun — Brigham and Women's Hospital
- Study coordinator: Dong, Xianjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.