Understanding the genetic and environmental factors in COPD progression
Multi-omic networks associated with COPD progression in TOPMed Cohorts
This study is looking into why some smokers get COPD while others don’t, by exploring both their genes and their environment, and it hopes to find new ways to treat and help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10592280 on NIH RePORTER |
What this research studies
This research investigates why only a subset of smokers develops chronic obstructive pulmonary disease (COPD) by examining genetic and environmental influences. It utilizes advanced techniques like whole genome sequencing and proteomics to analyze data from multiple cohorts, including a significant number of African American participants. By integrating these diverse molecular profiles, the study aims to identify specific pathways that contribute to COPD progression, which could lead to targeted therapies and personalized treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include smokers and former smokers, particularly those with a family history of COPD or related respiratory conditions.
Not a fit: Patients who do not smoke or have never been exposed to tobacco smoke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and personalized care strategies for individuals at risk of developing COPD.
How similar studies have performed: Previous research has shown promise in using multi-omic approaches to understand complex diseases, indicating that this methodology could yield valuable insights into COPD.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kechris-Mays, Katherina — University of Colorado Denver
- Study coordinator: Kechris-Mays, Katherina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.