Understanding the genetic and environmental factors behind orofacial clefts
Investigating the role of genes, maternal exposures, and interactions on orofacial clefts
This study is looking at how genetics and things like drinking alcohol or smoking during pregnancy might affect the chances of having a baby with a cleft lip or palate, and it’s for families who want to help us learn more about these conditions to improve prevention.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10813780 on NIH RePORTER |
What this research studies
This research investigates how genetic variations and maternal environmental exposures, such as alcohol consumption and smoking during pregnancy, contribute to the risk of orofacial clefts, which are common birth defects. By analyzing data from families affected by these conditions, the study aims to identify specific genetic variants and their interactions with environmental factors. The goal is to better understand the causes of different cleft types and improve prevention strategies. Patients and families may be involved in providing data and samples to help advance this important research.
Who could benefit from this research
Good fit: Ideal candidates for participation include families with a history of orofacial clefts and individuals who have experienced these conditions.
Not a fit: Patients without a family history of orofacial clefts or those who do not have any congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for orofacial clefts, potentially reducing their occurrence in newborns.
How similar studies have performed: Previous research has successfully identified genetic risk factors for orofacial clefts, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Shaffer, John R — University of Pittsburgh at Pittsburgh
- Study coordinator: Shaffer, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.