Understanding the genetic and clinical differences in complex diseases
Official title: PATHFINDER: Finding the genomic and clinical pathways underlying heterogeneity in complex disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10865841 · Data updated 2026-11-12
This study is looking at how our genes and health can affect conditions like schizophrenia, inflammatory bowel disease, and heart disease, so that doctors can create more personalized treatments that work better for each patient.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $151,956 |
| NIH project number | 1K99HG013547-01 |
| Project ID | NIH-10865841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia, inflammatory bowel disease, or coronary artery disease.
✕Less likely to help
Patients with rare diseases or those not diagnosed with the targeted complex diseases may not receive any benefit from this research.
What this research studies
This research aims to uncover the underlying genetic and clinical factors that contribute to the variability seen in complex diseases like schizophrenia, inflammatory bowel disease, and coronary artery disease. By utilizing advanced statistical genetics and genomic data, the project seeks to identify specific genes and their interactions that may influence disease outcomes. Patients will benefit from a more tailored approach to treatment based on their unique genetic profiles, potentially leading to better management of their conditions.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with complex diseases.
How similar studies have gone: Previous research has shown promise in using genomic data to understand disease heterogeneity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Garcia Gonzalez, Judit — Icahn School of Medicine at Mount Sinai
- Study coordinator: Garcia Gonzalez, Judit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.