Understanding the genes that cause glaucoma
Determining Molecular Mechanisms of Human Glaucoma Genes
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11061827
This study is looking into how a specific gene called GLIS1 affects glaucoma, which can lead to vision loss, and aims to find new ways to help prevent or slow down the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11061827 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to glaucoma, a leading cause of blindness. It focuses on the GLIS1 gene, which is linked to high intraocular pressure and impaired drainage of eye fluid. By using advanced mouse models and genetic analysis, the study aims to uncover how GLIS1 and its interactions with other genes affect eye health. The findings could lead to new targeted therapies to prevent or slow the progression of glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma, particularly those with a family history of the disease or elevated intraocular pressure.
Not a fit: Patients with glaucoma who do not have genetic factors related to GLIS1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent blindness caused by glaucoma.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to glaucoma, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAIR, KAYARAT SAIDAS — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: NAIR, KAYARAT SAIDAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.