Understanding the genes involved in preeclampsia using human placenta cells
Official title: Elucidation of the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system
Funded at University of Texas at Austin · NIH-10870500 · Data updated 2026-11-12
This study is looking at how certain genes might play a role in preeclampsia, a serious condition that can happen during pregnancy, to help us understand what goes wrong with the placenta and find ways to improve care for expectant moms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $191,965 |
| NIH project number | 1R21HD115116-01 |
| Project ID | NIH-10870500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals who are at risk of developing preeclampsia or have been diagnosed with the condition.
✕Less likely to help
Patients who are not pregnant or those who have no history of preeclampsia may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to preeclampsia, a serious pregnancy complication. By using human trophoblast stem cells, the study aims to identify key transcription factors that regulate gene expression related to preeclampsia. The researchers will explore how these factors disrupt normal placental development and function, which is crucial for healthy pregnancies. The findings could lead to better understanding and potential interventions for preeclampsia.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for preeclampsia, enhancing maternal and fetal health outcomes.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in pregnancy complications, but this specific approach using trophoblast stem cells is relatively novel.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Kim, Jonghwan — University of Texas at Austin
- Study coordinator: Kim, Jonghwan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.