Understanding the genes behind congenital hydrocephalus using frog models
Analysis of Congenital Hydrocephalus Genes in Xenopus
This study is looking at congenital hydrocephalus, a condition where fluid builds up in the brain, using frogs to help understand the genes that might cause it, which could lead to better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11092703 on NIH RePORTER |
What this research studies
This research investigates congenital hydrocephalus, a serious birth defect characterized by the accumulation of cerebrospinal fluid in the brain. By using the frog Xenopus as a model, researchers aim to explore the genetic factors that contribute to this condition. The study employs advanced imaging techniques and gene-editing tools to analyze how different genes affect brain structure and fluid dynamics. This approach could lead to a better understanding of the disease and potentially new treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children diagnosed with congenital hydrocephalus or those with a family history of the condition.
Not a fit: Patients with hydrocephalus caused by non-genetic factors or those who are adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for congenital hydrocephalus, reducing the need for surgical interventions.
How similar studies have performed: Previous research using animal models has shown promise in understanding genetic contributions to various congenital conditions, suggesting potential success for this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Deniz, Engin — Yale University
- Study coordinator: Deniz, Engin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.