Understanding the α-Gal syndrome and its effects on patients
Investigation of the prevalence, presentation and immunologic features of the α-Gal syndrome in a high-risk cohort not recruited on the basis of allergic disease
This study is looking into α-Gal syndrome, which can cause allergic reactions to meat from mammals after tick bites, and it's for anyone who might be affected, even if they don't have known allergies, to help understand how common it is and how people's bodies react to these foods.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10670058 on NIH RePORTER |
What this research studies
This research investigates the α-Gal syndrome, a condition causing delayed allergic reactions to mammalian meat, particularly after tick bites. It aims to explore the prevalence and immunologic features of this syndrome in a diverse group of individuals, not just those with known allergic diseases. By examining how patients react to mammalian meat and dairy, the study seeks to identify those who may be sensitized to the α-Gal antigen and understand the broader implications of this condition. Patients may undergo assessments to determine their immune response and symptoms related to α-Gal sensitization.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who experience allergic reactions after consuming mammalian meat or dairy products, particularly those with unexplained gastrointestinal symptoms.
Not a fit: Patients who do not consume mammalian meat or dairy and do not experience related allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and management strategies for individuals affected by α-Gal syndrome.
How similar studies have performed: Previous research has indicated that understanding the immunologic features of α-Gal syndrome can lead to improved patient outcomes, suggesting that this approach has potential for success.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Wilson, Jeffrey M — University of Virginia
- Study coordinator: Wilson, Jeffrey M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.