Understanding the functions of proteins in bacteria
Structure-based functional annotation of microbial genomes
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10886784
This study is looking at how certain proteins in bacteria work, especially in harmful germs, to help us understand them better and find new ways to treat infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10886784 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying the functions and roles of proteins in various bacterial genomes, particularly those of non-model microbes like pathogens. By utilizing advanced computational methods, including structural predictions and deep learning, the team aims to annotate poorly understood proteins that make up a significant portion of bacterial proteomes. This work could lead to better insights into bacterial behavior and potential therapeutic targets for diseases caused by these microbes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by bacterial infections or diseases caused by poorly understood microbial pathogens.
Not a fit: Patients with conditions unrelated to bacterial infections or those caused by well-characterized microbes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of bacterial infections and lead to the development of new treatments.
How similar studies have performed: Other research has shown promise in using computational methods for protein annotation, indicating that this approach could yield significant insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREDDOLINO, LYDIA PETRA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: FREDDOLINO, LYDIA PETRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.