Understanding the flexibility and dynamics of functional nucleic acids
Official title: Developing an integrated system for detailing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides
Funded at West Virginia University · NIH-11127437 · Data updated 2026-11-12
This study is looking at how certain important molecules in our bodies, called oligonucleotides, move and change shape, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $486,400 |
| NIH project number | 5R01GM153899-02 |
| Project ID | NIH-11127437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to nucleic acid dysfunction or diseases where oligonucleotides play a critical role.
✕Less likely to help
Patients with conditions unrelated to nucleic acids or those not affected by molecular dynamics may not receive any benefit from this research.
What this research studies
This research focuses on developing a new system to analyze the structural flexibility and dynamics of functional oligonucleotides, which are essential for various biological processes. By utilizing advanced techniques like mass spectrometry and ion mobility spectrometry, the researchers aim to overcome current limitations in characterizing these molecules. The goal is to provide a clearer picture of how these nucleic acids behave in different environments, which could lead to better understanding and treatment of diseases. Patients may benefit from insights gained into the molecular mechanisms of diseases linked to nucleic acids.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for diseases involving functional nucleic acids.
How similar studies have gone: While the approaches used in this research are promising, they are still being developed and have not yet been widely tested in similar studies.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Valentine, Stephen — West Virginia University
- Study coordinator: Valentine, Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.