Understanding the factors behind opioid and stimulant use patterns to improve treatment

Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: Implications for improving care

NIH-funded research University of Michigan at Ann Arbor · NIH-10584684

This study is looking at why some people use both opioids and stimulants together, focusing on personal, social, and community influences, to find ways to help those at risk, especially those who might not get the support they need.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-10584684 on NIH RePORTER

What this research studies

This research investigates the reasons and preferences that lead to polysubstance use involving opioids and stimulants, particularly focusing on individual, social, and community factors. It aims to identify modifiable motivators that drive high-risk behaviors, such as the use of synthetic opioids and intravenous drug use. By applying behavioral economic theory, the study seeks to understand how substance use preferences are influenced by the perceived value of drugs and the underestimation of overdose risks. The findings will help tailor treatment services for individuals struggling with these issues, especially those who are less likely to receive effective care.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing issues related to opioid and stimulant use.

Not a fit: Patients who do not engage in polysubstance use or who are not affected by opioid-related issues may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment strategies for individuals with opioid-involved polysubstance use, ultimately reducing overdose deaths.

How similar studies have performed: Previous research has shown that understanding individual and community factors can significantly improve treatment outcomes for substance use disorders, indicating a promising approach.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.