Understanding the environment of pediatric solid tumors
Pediatric Solid Tumor Microenvironment Atlas
['FUNDING_U01'] · CHILDREN'S HOSPITAL OF LOS ANGELES · NIH-10995230
This study is looking at the special surroundings of certain childhood tumors to find out why they can be hard to treat, with the goal of discovering new ways to help kids with these cancers have better outcomes and fewer side effects from treatment.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSPITAL OF LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10995230 on ClinicalTrials.gov |
What this research studies
This research investigates the unique characteristics of the microenvironments surrounding pediatric solid tumors, which differ from those in adult cancers. By focusing on tumors such as rhabdomyosarcoma, neuroblastoma, and Wilms tumors, the study aims to identify specific cells and mechanisms that contribute to treatment resistance. The researchers will create a Pediatric Solid Tumor Microenvironment Atlas to uncover vulnerabilities in these tumors that could be targeted for better treatment outcomes. This comprehensive approach seeks to improve survival rates and reduce treatment-related side effects for young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk pediatric solid tumors such as rhabdomyosarcoma, neuroblastoma, or Wilms tumors.
Not a fit: Patients with non-solid tumors or those who are not within the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pediatric solid tumors, improving survival rates and reducing side effects.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments, but this specific approach to pediatric solid tumors is relatively novel.
Where this research is happening
LOS ANGELES, UNITED STATES
- CHILDREN'S HOSPITAL OF LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ASGHARZADEH, SHAHAB — CHILDREN'S HOSPITAL OF LOS ANGELES
- Study coordinator: ASGHARZADEH, SHAHAB
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.