Understanding the effects of traumatic brain injury on neurodegeneration
CONNECT-TBI
This study is looking at how brain injuries can lead to long-term changes in brain health, and it’s for anyone who has experienced a traumatic brain injury or related conditions, as researchers will be analyzing a lot of brain samples and data to better understand these effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10694155 on NIH RePORTER |
What this research studies
This research investigates the complex spectrum of neurodegenerative changes that can occur following traumatic brain injury (TBI). It aims to create a collaborative network of leading experts who will analyze a vast collection of brain tissue samples and clinical data from individuals affected by TBI and related disorders. By examining over 2800 existing TBI cases and 7000 samples from patients with neurodegenerative conditions, the research seeks to uncover the underlying mechanisms of TBI-related neurodegeneration. This comprehensive approach will help improve our understanding of how TBI impacts brain health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic brain injuries, particularly those with a history of repetitive mild TBI.
Not a fit: Patients who have not experienced any form of traumatic brain injury or related neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for patients suffering from neurodegenerative diseases linked to traumatic brain injury.
How similar studies have performed: Previous research has shown promising results in understanding neurodegenerative processes related to TBI, but this comprehensive approach is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Smith, Douglas Hamilton — University of Pennsylvania
- Study coordinator: Smith, Douglas Hamilton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.