Understanding the effects of stopping malaria prevention in young children in Mali
Official title: "Investigating the rebound effects of seasonal malaria chemoprevention (SMC) in Mali"
Funded at Univ of Sciences, Tech & Tech of Bamako · NIH-10898673 · Data updated 2026-11-12
This study looks at how stopping a special malaria prevention treatment for young children in Mali affects the number of malaria cases, helping us understand what works best to keep kids healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Sciences, Tech & Tech of Bamako NIH-funded |
| Lab location | 1 site (Bamako, Mali) |
| Project start | September 5, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $130,918 |
| NIH project number | 5R01AI169517-03 |
| Project ID | NIH-10898673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under five years old who have participated in the seasonal malaria chemoprevention program.
✕Less likely to help
Children over five years old or those who have not participated in the SMC program may not benefit from this research.
What this research studies
This research investigates the impact of seasonal malaria chemoprevention (SMC) on children under five years old in Mali. It focuses on how stopping SMC due to age restrictions affects malaria rates in both compliant and non-compliant children. By enrolling a large cohort, the study aims to compare malaria occurrences between those who received the full treatment and those who did not. The findings could help improve malaria prevention strategies in the region.
Why it matters
Potential benefit: If successful, this research could lead to better malaria prevention strategies that protect children from severe malaria infections.
How similar studies have gone: Previous studies have shown significant decreases in malaria cases with SMC, but this research aims to explore the less understood rebound effects, making it a novel investigation.
Where this research is happening
-
Univ of Sciences, Tech & Tech of Bamako
Bamako, Mali Active
Researchers
- Principal investigator: Toure, Mahamoudou — Univ of Sciences, Tech & Tech of Bamako
- Study coordinator: Toure, Mahamoudou
Related research
Other NIH-funded projects on the same topics.
-
Digital malaria surveillance in Ethiopia to improve outbreak detection
A collaboration to add a malaria-specific digital module to an existing surveillance system in Africa to help detect and respond to outbreaks faster.
-
Cross-sector partnership uses digital malaria surveillance in Ethiopia
A US-based team will adapt and test a digital malaria surveillance module in SORMAS to help detect and respond to malaria outbreaks in Ethiopia.
-
Malaria control project in Western Kenya to reduce illness and deaths
A large, multi-year effort in western Kenya will help track malaria spread and test ways to prevent transmission so fewer people get sick or die.
-
Optimizing tafenoquine dose to prevent relapse of vivax malaria in Asia
A study tests the best tafenoquine dose to prevent P. vivax malaria relapse in people in East Asia and Oceania.
-
Optimizing tafenoquine dose to prevent P. vivax malaria relapses in Asia
A study to find the best single-dose tafenoquine amount to prevent relapse of P. vivax malaria in people in East Asia and Oceania.
-
Severe malaria and brain risk in children
This grant studies how severe malaria in young children can affect brain development and long-term thinking and behavior, with a focus on kids in Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.