Understanding the effects of oxytocin on brain development after induced birth
Mapping postnatal oxytocinergic system and offspring neurobehavior after induced birth with oxytocin
This study is looking at how using oxytocin to help start labor might affect the brain and behavior of newborns, so we can better understand if it could lead to any developmental issues in children.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10888789 on NIH RePORTER |
What this research studies
This research investigates how the use of oxytocin during labor induction affects the developing brain and behavior of newborns. By creating a precise animal model that mimics human labor management, the study aims to explore the potential adverse effects of oxytocin on neurodevelopment. Researchers will analyze brain signaling pathways and gene expression related to social behavior in newborns exposed to oxytocin. The findings could provide insights into the relationship between labor induction practices and developmental disorders in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women considering labor induction with oxytocin and their newborns.
Not a fit: Patients who have not been induced with oxytocin or those whose children are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of the risks associated with oxytocin use during labor, potentially guiding safer practices for mothers and their newborns.
How similar studies have performed: While there have been studies on oxytocin's effects, this research employs a novel animal model to specifically address the mechanistic links to neurodevelopmental outcomes, making it a unique approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Palanisamy, Arvind — Washington University
- Study coordinator: Palanisamy, Arvind
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.