Understanding the early signs of chronic graft-versus-host disease after blood stem cell transplants
Biologic correlatives of chronic GVHD onset
This study is looking at early signs of chronic graft-versus-host disease (cGVHD) that can happen after blood stem cell transplants, focusing on changes in the skin, eyes, mouth, and blood to help find better ways to detect and treat the condition early on.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10674533 on NIH RePORTER |
What this research studies
This research investigates chronic graft-versus-host disease (cGVHD), a serious condition that can develop after blood stem cell transplants. It aims to identify early changes in the skin, eyes, mouth, and blood that occur before the clinical onset of cGVHD. By studying the immune response and the role of various cells and proteins, the research seeks to uncover the underlying mechanisms of cGVHD and explore new testing strategies for early detection. This could lead to targeted treatments that may prevent or mitigate the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone allogeneic hematopoietic cell transplantation and are at risk for developing cGVHD.
Not a fit: Patients who have not undergone blood stem cell transplants or those who do not have a risk of cGVHD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective treatments for patients at risk of developing cGVHD.
How similar studies have performed: Other research has shown promise in understanding immune responses in transplant patients, but the specific focus on early detection of cGVHD through this approach is relatively novel.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Lee, Stephanie J — Fred Hutchinson Cancer Center
- Study coordinator: Lee, Stephanie J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.