Understanding the early signs of Alzheimer's disease through tau pathology
Tracking the origin of tau pathology
This study is looking at how changes in a specific part of the brain might signal early signs of Alzheimer's disease, helping us find ways to spot people at risk before symptoms show up, so they can get help sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10573194 on NIH RePORTER |
What this research studies
This research investigates how tau pathology develops in the brain and its relationship with cognitive decline in individuals, particularly focusing on the locus coeruleus (LC) as an early indicator. By using advanced imaging techniques, the study aims to identify changes in the brain that occur long before symptoms of Alzheimer's disease appear. Participants will undergo a series of brain scans and cognitive assessments to track these changes over time. The goal is to improve the identification of individuals at risk for Alzheimer's, allowing for earlier interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 40 and older who may be at risk for Alzheimer's disease but do not yet show symptoms.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease or those under 40 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, potentially delaying or preventing cognitive decline.
How similar studies have performed: Previous research has shown promise in using imaging techniques to track Alzheimer's pathology, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Jacobs, Heidi Irma — Massachusetts General Hospital
- Study coordinator: Jacobs, Heidi Irma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.