Understanding the early drivers and protectors of autoimmune diseases like lupus
Official title: Autoimmune Drivers and Protectors Team Science (ADAPTS)
Funded at Oklahoma Medical Research Foundation · NIH-11030242 · Data updated 2026-11-12
This study is looking at what causes systemic lupus erythematosus (SLE) to help find ways to prevent it, especially for women and minority groups, by examining immune responses in nearly 11,000 people.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,249,430 |
| NIH project number | 5U01AI176244-03 |
| Project ID | NIH-11030242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for lupus, particularly women of child-bearing age and those from minority populations.
✕Less likely to help
Patients who already have advanced systemic lupus erythematosus or other severe autoimmune diseases may not benefit from this research.
What this research studies
This research investigates systemic lupus erythematosus (SLE), a complex autoimmune disease that can lead to serious health issues, particularly in women and minority populations. The team aims to identify factors that contribute to the onset of SLE before it fully develops, focusing on the role of activated B cells and other immune responses. By analyzing data from nearly 11,000 participants, the research seeks to uncover patterns and biomarkers that could help in preventing the disease and reducing its impact on patients' lives.
Why it matters
Potential benefit: If successful, this research could lead to early interventions that prevent the onset of lupus and reduce the risk of severe complications.
How similar studies have gone: Previous research has shown promise in identifying early biomarkers and immune responses in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: James, Judith a — Oklahoma Medical Research Foundation
- Study coordinator: James, Judith a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.