Understanding the early changes in basal-like breast cancer development
A premalignant chronology of cell-state variability in basal-like breast cancer
This study is looking at how certain changes in breast cells can lead to basal-like breast cancer, especially in African American women, using a special mouse model to help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11212009 on NIH RePORTER |
What this research studies
This research investigates the early cellular changes that lead to basal-like breast cancer, particularly in African American women. Using a novel mouse model, the study aims to identify how specific genetic alterations in breast cells contribute to the disease's progression. By examining the immune response and cellular variability in these early stages, researchers hope to uncover critical insights that could inform future treatments. The approach combines advanced genetic techniques with innovative methods to analyze cell behavior without disrupting their natural state.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American women who are at risk for or have been diagnosed with basal-like breast cancer.
Not a fit: Patients with other subtypes of breast cancer or those who do not identify as African American may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new strategies for preventing or treating basal-like breast cancer.
How similar studies have performed: While the specific approach of using the MADM model is relatively novel, similar studies have shown promise in understanding the genetic underpinnings of breast cancer.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Janes, Kevin a — University of Virginia
- Study coordinator: Janes, Kevin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.