Understanding the diversity and adaptability of lung cancer cells
Lineage heterogeneity and plasticity in lung cancer
This study is looking at how lung cancer cells can change and resist treatment, with the goal of finding out which specific types of lung cancer might respond better to different therapies, so that doctors can offer more personalized and effective treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10759017 on NIH RePORTER |
What this research studies
This research investigates the complex nature of lung cancer cells, focusing on how they can change and adapt, which often leads to treatment resistance. By analyzing genetic alterations in these cells, the study aims to identify different subgroups of lung cancer that may respond uniquely to therapies. The researchers will explore specific genes that are crucial for the survival of certain cancer cells, potentially revealing new targets for treatment. This approach could enhance the precision of therapies and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with lung cancer, particularly those experiencing treatment resistance.
Not a fit: Patients with early-stage lung cancer who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for lung cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting genetic vulnerabilities in cancer cells, suggesting that this approach could be effective.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Watanabe, Hideo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Watanabe, Hideo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.