Understanding the different types of immune responses in psoriasis and psoriatic arthritis
ELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium
This study is looking at how the immune system behaves in people with psoriasis and psoriatic arthritis to better understand how psoriasis can lead to arthritis, and it’s for anyone affected by these conditions who wants to learn more about their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11030293 on NIH RePORTER |
What this research studies
This research investigates the various immune responses associated with psoriatic spectrum diseases, which include psoriasis and psoriatic arthritis. By assembling a multidisciplinary team, the project aims to analyze clinical data and biosamples from diverse patient cohorts to identify distinct immune endotypes and their relationship to disease phenotypes. The study will also explore how immune cells interact with each other and their environment, including the microbiome, at a single-cell level. This comprehensive approach seeks to enhance our understanding of how psoriasis can progress to psoriatic arthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with various forms of psoriasis or psoriatic arthritis.
Not a fit: Patients with other unrelated skin conditions or autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with psoriasis and psoriatic arthritis.
How similar studies have performed: Previous research has shown promise in understanding immune responses in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Ritchlin, Christopher Trevor — University of Rochester
- Study coordinator: Ritchlin, Christopher Trevor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.