Understanding the different causes of Alzheimer's disease
Official title: Discovering Heterogeneous Causal Pathophysiology of Alzheimer's Disease
Funded at University of California Berkeley · NIH-11135114 · Data updated 2026-11-12
This study is looking into how Alzheimer's disease affects different groups of people and aims to find the best ways to treat it by understanding the roles of certain proteins in the brain, so that future treatments can be more personalized and effective for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $372,690 |
| NIH project number | 1R01AG089512-01A1 |
| Project ID | NIH-11135114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those who may respond differently to current treatments based on their unique biological profiles.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the complex causes of Alzheimer's disease (AD) by analyzing existing data to identify how different subpopulations are affected by the disease. The team will develop new statistical methods to uncover the relationships between Amyloid-beta and tau proteins and their impact on cognitive function. By understanding these relationships, the research aims to determine the best timing and target groups for treatments that lower these proteins. This approach could lead to more effective treatment strategies tailored to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for Alzheimer's disease, improving cognitive outcomes for patients.
How similar studies have gone: Previous research has shown promise in understanding Alzheimer's disease through similar statistical approaches, indicating potential for success in this novel investigation.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Wang, Jingshen — University of California Berkeley
- Study coordinator: Wang, Jingshen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.