Understanding the differences in protein inclusions related to Alzheimer's disease
Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell Models
This study is looking at how different types of a protein called alpha-synuclein behave in brain cells to help us understand Alzheimer's disease and similar conditions, so we can learn more about what causes memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10978182 on NIH RePORTER |
What this research studies
This research investigates the biological differences between various forms of alpha-synuclein inclusions in human stem-cell models, which are crucial for understanding Alzheimer's disease and related dementias. By examining how these misfolded proteins behave and interact within neurons, the study aims to uncover the mechanisms behind their formation and their impact on cognitive decline. The approach involves using advanced cellular models to simulate the conditions of Alzheimer's pathology, allowing researchers to observe the progression and characteristics of these inclusions in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those exhibiting symptoms associated with alpha-synuclein pathology.
Not a fit: Patients with forms of dementia not related to alpha-synuclein inclusions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Alzheimer's disease, potentially paving the way for innovative treatments.
How similar studies have performed: Previous research has shown promising results in understanding protein misfolding in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Khurana, Vikram — Brigham and Women's Hospital
- Study coordinator: Khurana, Vikram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.