Understanding the differences in protein inclusions related to Alzheimer's disease
Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell Models
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10835007
This study is looking at how different types of a protein called alpha-synuclein behave in brain cells to help us understand Alzheimer's disease and related memory problems, with the hope of finding new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10835007 on ClinicalTrials.gov |
What this research studies
This research investigates the biological differences between various forms of alpha-synuclein inclusions in human stem-cell models, which are crucial in understanding Alzheimer's disease and related dementias. By examining how these misfolded proteins behave and interact within neurons, the study aims to uncover the mechanisms behind their formation and their impact on cognitive decline. The approach involves using advanced techniques to analyze the structural characteristics of these inclusions and their effects on brain cells. This could lead to insights into the progression of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those with a focus on the role of alpha-synuclein.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights that lead to new treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Other research has shown promising results in understanding protein misfolding in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHURANA, VIKRAM — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KHURANA, VIKRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease