Understanding the differences in human pancreas structure
Heterogeneity of the human pancreas
This study is looking at how the amount and arrangement of insulin-producing cells in the pancreas can change in people with diabetes, using advanced imaging to gather detailed information that could help future research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10538549 on NIH RePORTER |
What this research studies
This research investigates the variability in pancreatic beta-cell mass, which is crucial for diabetes progression. By analyzing human pancreas samples, the study aims to quantify beta-cell mass and understand the spatial arrangement of islets within the pancreas. The researchers will use advanced imaging techniques and large-scale quantification methods to gather comprehensive data, which will help clarify the role of beta-cell heterogeneity in diabetes. Ultimately, this work seeks to create a Virtual Repository Database to store and share findings for future research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diabetes as well as non-diabetic individuals who are willing to donate pancreas tissue for analysis.
Not a fit: Patients who are not undergoing any form of pancreatic analysis or those with conditions unrelated to pancreatic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diabetes by identifying critical factors related to beta-cell function.
How similar studies have performed: Previous research has shown success in understanding pancreatic function through tissue analysis, but this study aims to provide a more comprehensive and detailed approach.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hara, Manami — University of Chicago
- Study coordinator: Hara, Manami
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.