Understanding the development of the anterior lobe of the cerebellum.
Meander tail and development of the anterior lobe.
This study is looking at how a part of the brain called the anterior lobe of the cerebellum grows and changes when certain genetic mutations are present, using a special mouse model that shows unique developmental issues, to help us understand more about brain disorders.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11075263 on NIH RePORTER |
What this research studies
This research investigates how the anterior lobe of the cerebellum develops and how it is affected by specific genetic mutations. Using advanced genomic tools, the study aims to identify mutations linked to the meander tail mouse model, which exhibits unique developmental disorders. By analyzing these mutations, researchers hope to uncover the underlying mechanisms that differentiate the anterior and posterior compartments of the cerebellum. This work could provide insights into developmental and degenerative disorders affecting the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with genetic mutations affecting cerebellar development or function.
Not a fit: Patients without any known genetic mutations related to cerebellar disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cerebellar disorders, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown promise in understanding genetic mutations affecting brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Hamilton, Bruce a — University of California, San Diego
- Study coordinator: Hamilton, Bruce a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.