Understanding the development and disorders of the lower jaw
Cartilage and bone of the lower jaw in development and disease
This study looks at how the lower jaw grows and the problems that can happen during its development, especially focusing on a temporary structure called Meckel's cartilage, to help understand common jaw-related birth defects that can affect breathing, speaking, and eating.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11005702 on NIH RePORTER |
What this research studies
This research investigates how the lower jaw, particularly the mandible, develops and the disorders that can arise during this process. It focuses on the role of Meckel's cartilage, a temporary structure in embryonic development, and its relationship to jaw size and shape. By using advanced imaging techniques, the study aims to uncover the mechanisms behind common birth defects affecting the jaw, which can lead to complications such as airway obstruction and difficulties with speech and feeding. The research employs a combination of biological analysis and imaging to explore these developmental processes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and children with diagnosed mandibular disorders or related birth defects.
Not a fit: Patients with fully developed jaws or those without any jaw-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for jaw-related birth defects, enhancing the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding jaw development and related disorders, indicating that this approach has potential for success.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Perrine, Susan Marie — Pennsylvania State University, the
- Study coordinator: Perrine, Susan Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.