Understanding the development and blood supply of intestinal tissue
Development and vascularity of intestinal mesenchyme
This study looks at how a special type of tissue helps adult intestinal stem cells grow and work properly, which could lead to better understanding and treatments for intestinal diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11087720 on NIH RePORTER |
What this research studies
This research investigates how the mesenchyme, a type of connective tissue, supports the growth and function of intestinal stem cells in adults. By examining the interactions between these cells and their environment, the study aims to uncover the mechanisms that regulate intestinal health and development. The research utilizes advanced cellular characterization techniques to identify key cell types and their roles in maintaining the intestinal structure and function. Patients may benefit from insights gained into intestinal diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with gastrointestinal disorders or those interested in the biological mechanisms of intestinal health.
Not a fit: Patients with non-intestinal related health issues or those outside the age range of 21+ years may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for intestinal disorders by enhancing our understanding of intestinal tissue development and maintenance.
How similar studies have performed: Other research has shown success in understanding similar cellular interactions in the intestine, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Shivdasani, Ramesh a — Dana-Farber Cancer Inst
- Study coordinator: Shivdasani, Ramesh a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.