Understanding the connection between the liver and pancreas in diabetes using advanced imaging techniques
Official title: Quantitative characterization of the liver-pancreas axis in diabetes via multiparametric magnetic resonance elastography
Funded at Mayo Clinic Rochester · NIH-11093551 · Data updated 2026-11-12
This study is looking at how nonalcoholic fatty liver disease affects diabetes-related processes in the body, especially between the liver and pancreas, to help people with prediabetes or diabetes find better ways to manage their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 9, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $399,749 |
| NIH project number | 5R01DK136731-03 |
| Project ID | NIH-11093551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who are diagnosed with prediabetes or type 2 diabetes mellitus.
✕Less likely to help
Patients without any metabolic disorders or those under 21 years old may not receive any benefit from this research.
What this research studies
This research investigates how nonalcoholic fatty liver disease (NAFLD) affects metabolic pathways related to diabetes, particularly focusing on the liver-pancreas axis. By utilizing advanced multiparametric magnetic resonance elastography (MRE), the study aims to visualize and analyze abnormalities in these organs and their relationship to insulin action and secretion. The goal is to gain insights into the progression from prediabetes to type 2 diabetes mellitus (T2DM) and to identify potential intervention points. Patients with prediabetes or diabetes may benefit from the findings, which could lead to improved management strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of diabetes and its complications related to liver health.
How similar studies have gone: Previous research has shown promising results in using imaging techniques to study metabolic diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Yin, Meng — Mayo Clinic Rochester
- Study coordinator: Yin, Meng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.