Understanding the connection between skin and nerves in atopic dermatitis itch
Integrin receptor: A connecting link between skin and peripheral sensing neurons in atopic dermatitis
This research explores how skin and nerve cells communicate to cause the persistent itch experienced by children and adolescents with atopic dermatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-11138744 on NIH RePORTER |
What this research studies
Atopic dermatitis is a common skin condition, especially in young people, known for its chronic itch that current treatments only temporarily relieve. This project aims to uncover the specific signals and pathways in the body that lead to this long-lasting itch. We believe that certain molecules released from skin cells trigger specific nerve cells, leading to the sensation of chronic itch. By identifying these key molecules and nerve pathways, we hope to find new ways to stop the itch at its source.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients, particularly children and adolescents, who experience chronic itch due to atopic dermatitis.
Not a fit: Patients without atopic dermatitis or those whose itch is caused by different conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for the chronic itch associated with atopic dermatitis, offering significant relief to patients.
How similar studies have performed: Current treatments for chronic atopic dermatitis itch are often temporary, indicating that this approach to uncover specific neurological pathways is novel and largely unexplored.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Mishra, Santosh K. — North Carolina State University Raleigh
- Study coordinator: Mishra, Santosh K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.