Understanding the connection between fats, inflammation, and brain decline in Alzheimer's disease
A link between lipid-mediated signaling and inflammation during neurodegeneration
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11099935
This project explores how certain fats and inflammation are connected in the brain changes seen in Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11099935 on ClinicalTrials.gov |
What this research studies
Alzheimer's disease involves brain changes like inflammation, stress, and issues with cell energy. This work looks at how specific fat-carrying proteins, called FABPs, might contribute to inflammation in brain cells called astrocytes. Researchers believe that by understanding how these proteins work, we can learn more about how Alzheimer's develops. The goal is to uncover new ways to protect brain cells and slow down the disease process.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to help those affected by Alzheimer's disease dementia in the future.
Not a fit: Patients seeking immediate treatment options may not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target inflammation and fat metabolism in the brain to slow the progression of Alzheimer's disease.
How similar studies have performed: While the role of inflammation in Alzheimer's is known, this specific link involving FABP7 and lipid-mediated signaling is a newer area of exploration.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEHAR, MARIANA ATINA — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: PEHAR, MARIANA ATINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome