NIH-funded research R21 grant

Understanding the Connection Between Childhood Abuse and Gynecologic Health

Official title: Child Abuse and Risk of Gynecologic Disease in a North American Cohort

Funded at Boston University Medical Campus · NIH-11175971 · Data updated 2026-11-12

This research explores how experiences of childhood abuse might be connected to common gynecologic conditions like fibroids, endometriosis, and PCOS in women.

More Gynecologic Disease research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionBoston University Medical Campus
NIH-funded
Lab location1 site (Boston, United States)
Project startAugust 23, 2024
Project endJuly 31, 2026
Funding year2025
Award (this year)$210,565
NIH project number5R21HD114017-02
Project IDNIH-11175971 on NIH RePORTER

Who could benefit from this research

Could help

This research focuses on understanding past experiences and health outcomes in female-identified participants from a North American cohort.

Less likely to help

Patients not experiencing gynecologic conditions or childhood abuse may not directly benefit from this specific research.

What this research studies

Many women experience debilitating gynecologic conditions such as uterine fibroids, endometriosis, and polycystic ovarian syndrome (PCOS), which can cause pain, infertility, and heavy bleeding. We know that childhood sexual abuse is unfortunately common, and emerging evidence suggests it might affect long-term health, including gynecologic health. This project aims to understand this connection better by looking at data from a large group of women. By understanding how early life experiences might influence these conditions, we hope to find new ways to support women's health.

Why it matters

Potential benefit: If successful, this work could lead to better prevention strategies and more informed care for women who have experienced childhood abuse and are at risk for or have gynecologic conditions.

How similar studies have gone: While there has been limited study in this specific area, previous work by the principal investigators and emerging research suggest a link between early life abuse and gynecologic conditions.

Where this research is happening

  • Boston University Medical Campus
    Boston, United States
    Active

Researchers

  • Principal investigator: Wise, Lauren a — Boston University Medical Campus
  • Study coordinator: Wise, Lauren a

Related research

Other NIH-funded projects on the same topics.

  • The impact of childhood abuse on women's gynecologic health

    This study looks at how childhood sexual abuse might affect women's health later in life, specifically regarding conditions like fibroids, endometriosis, and polycystic ovary syndrome, and it aims to find ways to help women cope with any related issues like pain or infertility.

    NIH research Boston University Medical Campus · Boston, United States · NIH-10789719

  • GYN-AIDE: AI-Driven Education to Help Gynecologic Cancer Patients

    This study tests an AI chatbot to help endometrial cancer patients learn about care and HPV vaccination, and to see if using the chatbot influences vaccination uptake in a gynecologic oncology clinic.

    Recruiting University of Southern California · Los Angeles, California · NCT07279571

  • Awareness and help-seeking for gynecological problems in Hong Kong

    This project tries to see if awareness, knowledge, and help-seeking differ between women with gynecological conditions and the general public in Hong Kong using a questionnaire.

    Recruiting Chinese University of Hong Kong · Hong Kong · NCT07208383

  • Molecular and cellular analysis of uterine lavage from gynecologic surgery

    This will try a new uterine lavage catheter to collect samples from up to 50 adults having gynecologic surgery to see what cells are present.

    Recruiting Stanford University · Palo Alto, California · NCT07044505

  • Cabergoline plus coasting to reduce ovarian hyperstimulation syndrome

    This test checks whether adding cabergoline to coasting lowers the chance of ovarian hyperstimulation syndrome in women at high risk during gonadotropin ovarian stimulation.

    Recruiting Phase 2 Tanta University · Damietta, New Damietta · NCT07043322

  • Gynecological Ultrasound Image Bank for Diagnostics and AI

    This project will collect gynecological ultrasound images from adult patients at a Rome hospital to build a large database for clinician training, research, and AI diagnostic tools.

    Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07031921

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.