Understanding the complexities of frontotemporal degeneration and aging
From cells to complex syndromes: using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging
['FUNDING_P01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10889924
This study is looking at how a protein called TDP-43 affects frontotemporal degeneration (FTD), a type of dementia that can happen in younger people, to help us better understand the disease and find new ways to treat it, and we invite patients to join by sharing their experiences and health information.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10889924 on ClinicalTrials.gov |
What this research studies
This research investigates frontotemporal degeneration (FTD), a common form of dementia in individuals under 65, particularly focusing on the role of TDP-43 protein in the disease's progression. The study aims to bridge the gap between cellular models and human clinical manifestations by examining the molecular consequences of TDP-43 accumulation. By analyzing both familial and sporadic cases, the research seeks to enhance our understanding of the disease and inform future treatment strategies. Patients may contribute to this research through clinical assessments and biomarker evaluations.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with frontotemporal degeneration or amyotrophic lateral sclerosis, particularly those with familial histories of these conditions.
Not a fit: Patients with other forms of dementia unrelated to TDP-43 pathology may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for patients suffering from frontotemporal degeneration and related disorders.
How similar studies have performed: While there has been progress in understanding TDP-43 in experimental models, this research aims to explore uncharted territories in human disease, making it a novel approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCMILLAN, COREY T — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: MCMILLAN, COREY T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease