Understanding the complex genetic changes that drive tumor development
Official title: Defining the universal genomic language of hallmarks in tumor development
Funded at Boston Children's Hospital · NIH-10681670 · Data updated 2026-11-12
This study is looking at how different genetic changes work together to help tumors grow, with the goal of finding better treatment options for people with complicated cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,593,000 |
| NIH project number | 1DP2CA290196-01 |
| Project ID | NIH-10681670 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with complex tumors that do not respond to traditional therapies targeting single mutations.
✕Less likely to help
Patients with tumors that have clear, actionable single driver mutations may not benefit from this research.
What this research studies
This research investigates the intricate genomic changes that lead to tumor development, focusing on the complex interactions of multiple mutations rather than just single 'driver' mutations. By utilizing advanced technologies such as machine learning and various genomic data types, the project aims to uncover 'genomic programs' that contribute to cancer progression. This comprehensive approach could lead to new insights into how tumors grow and evade treatment, ultimately aiming to improve therapeutic options for patients with complex cancers.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for a broader range of cancer patients by targeting the underlying genomic mechanisms of tumor growth.
How similar studies have gone: While the approach of focusing on complex genomic interactions is innovative, similar research has shown promise in understanding multifactorial aspects of cancer, suggesting potential for success.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Dietlein, Felix — Boston Children's Hospital
- Study coordinator: Dietlein, Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.