Understanding the complex cell networks in bone marrow
Official title: Unraveling the cell networks in bone marrow through transcriptomic and epigenetic profiling
Funded at University of Pennsylvania · NIH-11070693 · Data updated 2026-11-12
This study is looking at the different types of cells in our bone marrow to understand how they work together and affect our health as we get older, which could help improve treatments for blood and immune diseases like leukemia and conditions like osteoporosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $79,756 |
| NIH project number | 1F32HL178083-01 |
| Project ID | NIH-11070693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders, skeletal diseases, or those experiencing age-related health changes.
✕Less likely to help
Patients with conditions unrelated to bone marrow function or those who are not experiencing age-related changes may not benefit from this research.
What this research studies
This research investigates the intricate environment of bone marrow, which is crucial for various blood and immune diseases, as well as skeletal and vascular conditions. By utilizing advanced transcriptomic and epigenetic profiling techniques, the study aims to create a detailed map of the different cell types present in human bone marrow. This comprehensive approach will help uncover how these cells interact and contribute to health and disease, particularly as we age. The findings could lead to better understanding and treatment of conditions like leukemia, osteoporosis, and other related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for a range of diseases affecting the bone marrow and enhance our understanding of age-related health issues.
How similar studies have gone: Previous research has shown promise in understanding bone marrow cell dynamics, but this project aims to provide a more comprehensive and detailed analysis, making it a novel approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Duffy, Michael P — University of Pennsylvania
- Study coordinator: Duffy, Michael P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.