Understanding the cell wall structure of a bacteria linked to dental issues
Biosynthesis, structure and function of cell wall in Streptococcus mutans
This study is looking at the cell wall of a bacteria called Streptococcus mutans, which is known for causing cavities and other serious health issues, to understand how its structure works and how it sticks to surfaces, with the hope of finding new ways to treat infections caused by this bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10807093 on NIH RePORTER |
What this research studies
This research investigates the cell wall of Streptococcus mutans, a bacteria primarily responsible for dental caries and associated with serious conditions like bacteremia and infective endocarditis. The study aims to explore the molecular structure of specific carbohydrates in the bacteria's cell wall, focusing on modifications that may influence its function and pathogenicity. By employing mild, non-destructive methods, researchers will analyze the chemical structures and the processes involved in the bacteria's attachment mechanisms. This could lead to new insights into how this pathogen operates and how it might be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from dental caries or those at risk of developing infections related to Streptococcus mutans.
Not a fit: Patients who do not have dental issues or are not at risk for infections caused by this bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating dental caries and related infections.
How similar studies have performed: Previous research has shown promise in understanding bacterial cell wall structures, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Korotkova, Natalia — University of Kentucky
- Study coordinator: Korotkova, Natalia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.