Understanding the cell structures in brain tumors using advanced genetic techniques
Official title: Dissecting the cellular hierarchies of malignant gliomas by single-cell functional genomics
Funded at Massachusetts General Hospital · NIH-10881296 · Data updated 2026-11-12
This study is looking at the different types of cells in brain tumors called gliomas to understand how they grow and change, with the hope of finding better treatments that are more suited to each patient's unique tumor.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $391,612 |
| NIH project number | 4R37CA245523-06 |
| Project ID | NIH-10881296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with malignant gliomas, particularly those who are seeking advanced treatment options.
✕Less likely to help
Patients with non-malignant brain tumors or those who do not have gliomas may not receive any benefit from this research.
What this research studies
This research investigates the complex cellular hierarchies within malignant gliomas, a type of brain tumor, by utilizing single-cell functional genomics. The approach involves analyzing individual cells to uncover their genetic functions and interactions, which may reveal how these tumors develop and progress. By understanding these cellular dynamics, the research aims to identify potential therapeutic targets and improve treatment strategies for patients with gliomas. Patients may benefit from insights that could lead to more effective treatments tailored to their specific tumor characteristics.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with malignant gliomas.
How similar studies have gone: Previous research using single-cell genomics has shown promising results in understanding cancer biology, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Suva, Mario Luca — Massachusetts General Hospital
- Study coordinator: Suva, Mario Luca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.