Understanding the cell division process in Toxoplasma gondii
Deciphering the composite S-phase in Toxoplasma gondii
['FUNDING_R21'] · UNIVERSITY OF SOUTH FLORIDA · NIH-10908661
This study is looking at how the Toxoplasma gondii parasite, which can affect many people, divides and grows, and it aims to create a new tool to help find better and safer treatments for those who are more vulnerable, like people with weakened immune systems.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10908661 on ClinicalTrials.gov |
What this research studies
This research investigates the unique cell cycle mechanisms of the Toxoplasma gondii parasite, which affects a significant portion of the human population. The study aims to develop a new tool, a Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) probe, to explore the atypical S-phase of the parasite's cell division. By gaining insights into how this parasite divides and survives, the research seeks to identify potential targets for new anti-parasitic drugs that could be safer and more effective for patients, especially those who are immunocompromised.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised and at risk of Toxoplasma gondii infections.
Not a fit: Patients who are not infected with Toxoplasma gondii or who have a robust immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and less toxic treatments for Toxoplasma gondii infections.
How similar studies have performed: While the study of Toxoplasma gondii is ongoing, the approach of using innovative cell cycle indicators is relatively novel and has not been extensively tested in this context.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUVOROVA, ELENA — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: SUVOROVA, ELENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.